Drug interactions
Levomilnacipran + Naproxen
Severity: Moderate
Levomilnacipran and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SNRIs impair platelet serotonin uptake and, with NSAIDs such as naproxen, increase the risk of bleeding, especially gastrointestinal bleeding. The risk is higher in older adults and those with prior GI bleeding.
What this interaction means in plain words
Levomilnacipran and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Naproxen belongs to Musculoskeletal.
Why it happens
Reduced platelet serotonin content from SNRI therapy adds to NSAID-induced platelet inhibition and mucosal injury.
What to do
Monitor for signs of bleeding and consider a proton pump inhibitor in high-risk patients. Use the lowest effective NSAID dose or prefer paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Naproxen?
MediHelp rates the interaction as moderate. Levomilnacipran and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SNRIs impair platelet serotonin uptake and, with NSAIDs such as naproxen, increase the risk of bleeding, especially gastrointestinal bleeding. The risk is higher in older adults and those with prior GI bleeding.
How serious is the interaction between Levomilnacipran and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and consider a proton pump inhibitor in high-risk patients. Use the lowest effective NSAID dose or prefer paracetamol.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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