Drug interactions
Levomilnacipran + Safinamide
Severity: Contraindicated
Levomilnacipran and Safinamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran is a serotonin-norepinephrine reuptake inhibitor, and combining it with a MAO inhibitor such as safinamide can cause serotonin syndrome and hypertensive reactions. This can be life-threatening.
What this interaction means in plain words
Levomilnacipran and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levomilnacipran belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
Reuptake inhibition plus MAO inhibition leads to excessive synaptic serotonin and norepinephrine.
What to do
Avoid the combination. Allow at least 14 days after stopping safinamide before starting levomilnacipran, and at least 7 days after stopping levomilnacipran before starting safinamide.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Safinamide?
MediHelp rates the interaction as contraindicated. Levomilnacipran and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levomilnacipran is a serotonin-norepinephrine reuptake inhibitor, and combining it with a MAO inhibitor such as safinamide can cause serotonin syndrome and hypertensive reactions. This can be life-threatening.
How serious is the interaction between Levomilnacipran and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Allow at least 14 days after stopping safinamide before starting levomilnacipran, and at least 7 days after stopping levomilnacipran before starting safinamide.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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