Drug interactions
Levomilnacipran + Selegiline
Severity: Contraindicated
Levomilnacipran and Selegiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran with an MAO inhibitor can cause serotonin syndrome and hypertensive reactions. Labeling contraindicates its use with MAOIs and within 14 days of stopping them.
What this interaction means in plain words
Levomilnacipran and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levomilnacipran belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Levomilnacipran inhibits serotonin and norepinephrine reuptake while MAO inhibition blocks their metabolism.
What to do
Do not coadminister. Allow at least 14 days after stopping selegiline before starting levomilnacipran, and at least 7 days after stopping levomilnacipran before starting an MAOI.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Selegiline?
MediHelp rates the interaction as contraindicated. Levomilnacipran and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levomilnacipran with an MAO inhibitor can cause serotonin syndrome and hypertensive reactions. Labeling contraindicates its use with MAOIs and within 14 days of stopping them.
How serious is the interaction between Levomilnacipran and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow at least 14 days after stopping selegiline before starting levomilnacipran, and at least 7 days after stopping levomilnacipran before starting an MAOI.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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