Drug interactions
Levonorgestrel + Mycophenolate mofetil
Severity: Moderate
Levonorgestrel and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate has been shown to modestly lower levonorgestrel exposure in some studies, although ovulation suppression was not clearly lost. Mycophenolate is teratogenic, so any loss of contraceptive reliability is important.
What this interaction means in plain words
Levonorgestrel and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levonorgestrel belongs to Endocrine; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Mechanism is not established; mycophenolate may modestly lower levonorgestrel concentrations.
What to do
Advise an additional barrier contraceptive method, as labeling recommends two forms of contraception with mycophenolate. Do not rely on hormonal contraception alone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Levonorgestrel
Frequently asked questions
Can I take Levonorgestrel with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Levonorgestrel and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolate has been shown to modestly lower levonorgestrel exposure in some studies, although ovulation suppression was not clearly lost. Mycophenolate is teratogenic, so any loss of contraceptive reliability is important.
How serious is the interaction between Levonorgestrel and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional barrier contraceptive method, as labeling recommends two forms of contraception with mycophenolate. Do not rely on hormonal contraception alone.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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