Drug interactions
Levonorgestrel + Ribociclib
Severity: Minor
Levonorgestrel and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and could raise systemic levonorgestrel levels. With the intrauterine system, systemic exposure is low, so a significant effect is unlikely. Ribociclib also requires effective non-hormonal contraception in some patients.
What this interaction means in plain words
Levonorgestrel and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levonorgestrel belongs to Endocrine; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, which may reduce levonorgestrel metabolism.
What to do
No dose adjustment is generally needed. Monitor for increased progestogenic effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levonorgestrel
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Levonorgestrel with Ribociclib?
MediHelp rates the interaction as minor. Levonorgestrel and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib is a moderate CYP3A4 inhibitor and could raise systemic levonorgestrel levels. With the intrauterine system, systemic exposure is low, so a significant effect is unlikely. Ribociclib also requires effective non-hormonal contraception in some patients.
How serious is the interaction between Levonorgestrel and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for increased progestogenic effects.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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