Drug interactions
Levonorgestrel + Sugammadex
Severity: Moderate
Levonorgestrel and Sugammadex: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sugammadex may bind progestogens and reduce their availability, so a single dose is considered equivalent to a missed dose of a hormonal contraceptive. Contraceptive protection may be temporarily reduced for systemic products.
What this interaction means in plain words
Levonorgestrel and Sugammadex can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levonorgestrel belongs to Endocrine; Sugammadex belongs to Miscellaneous.
Why it happens
Sugammadex encapsulates progestogen molecules, lowering free hormone exposure.
What to do
Advise an additional non-hormonal method for 7 days after sugammadex if using systemic hormonal contraception; follow missed-dose instructions for oral pills.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levonorgestrel
Other interactions of Sugammadex
- Desogestrel-ethinyl estradiol + Sugammadex Moderate
- Ethinyl estradiol-drospirenone + Sugammadex Moderate
- Ethinyl estradiol-levonorgestrel + Sugammadex Moderate
- Etonogestrel + Sugammadex Moderate
- Medroxyprogesterone + Sugammadex Moderate
- Norethisterone + Sugammadex Moderate
Frequently asked questions
Can I take Levonorgestrel with Sugammadex?
MediHelp rates the interaction as moderate. Levonorgestrel and Sugammadex can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sugammadex may bind progestogens and reduce their availability, so a single dose is considered equivalent to a missed dose of a hormonal contraceptive. Contraceptive protection may be temporarily reduced for systemic products.
How serious is the interaction between Levonorgestrel and Sugammadex?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal method for 7 days after sugammadex if using systemic hormonal contraception; follow missed-dose instructions for oral pills.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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