Drug interactions
Etonogestrel + Sugammadex
Severity: Moderate
Etonogestrel and Sugammadex: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sugammadex can bind progestogens and reduce their availability, so a single dose is treated like a missed hormonal contraceptive dose. Contraceptive protection may be temporarily reduced.
What this interaction means in plain words
Etonogestrel and Sugammadex can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etonogestrel belongs to Endocrine; Sugammadex belongs to Miscellaneous.
Why it happens
Sugammadex encapsulates progestogen molecules, lowering free hormone exposure.
What to do
For implant or ring users, add a non-hormonal back-up method for 7 days after sugammadex administration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etonogestrel
Other interactions of Sugammadex
- Desogestrel-ethinyl estradiol + Sugammadex Moderate
- Ethinyl estradiol-drospirenone + Sugammadex Moderate
- Ethinyl estradiol-levonorgestrel + Sugammadex Moderate
- Levonorgestrel + Sugammadex Moderate
- Medroxyprogesterone + Sugammadex Moderate
- Norethisterone + Sugammadex Moderate
Frequently asked questions
Can I take Etonogestrel with Sugammadex?
MediHelp rates the interaction as moderate. Etonogestrel and Sugammadex can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sugammadex can bind progestogens and reduce their availability, so a single dose is treated like a missed hormonal contraceptive dose. Contraceptive protection may be temporarily reduced.
How serious is the interaction between Etonogestrel and Sugammadex?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For implant or ring users, add a non-hormonal back-up method for 7 days after sugammadex administration.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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