Drug interactions
Medroxyprogesterone + Sugammadex
Severity: Moderate
Medroxyprogesterone and Sugammadex: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sugammadex may bind progestogens and reduce their availability. A bolus dose is treated as equivalent to a missed dose of hormonal contraception, so contraceptive protection may be reduced.
What this interaction means in plain words
Medroxyprogesterone and Sugammadex can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Medroxyprogesterone belongs to Endocrine; Sugammadex belongs to Miscellaneous.
Why it happens
Sugammadex's cyclodextrin structure encapsulates progestogen molecules, lowering free hormone exposure.
What to do
Counsel patients to use an additional non-hormonal contraceptive method for 7 days after sugammadex. For oral progestins, follow missed-dose guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Other interactions of Sugammadex
- Desogestrel-ethinyl estradiol + Sugammadex Moderate
- Ethinyl estradiol-drospirenone + Sugammadex Moderate
- Ethinyl estradiol-levonorgestrel + Sugammadex Moderate
- Etonogestrel + Sugammadex Moderate
- Levonorgestrel + Sugammadex Moderate
- Norethisterone + Sugammadex Moderate
Frequently asked questions
Can I take Medroxyprogesterone with Sugammadex?
MediHelp rates the interaction as moderate. Medroxyprogesterone and Sugammadex can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sugammadex may bind progestogens and reduce their availability. A bolus dose is treated as equivalent to a missed dose of hormonal contraception, so contraceptive protection may be reduced.
How serious is the interaction between Medroxyprogesterone and Sugammadex?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to use an additional non-hormonal contraceptive method for 7 days after sugammadex. For oral progestins, follow missed-dose guidance.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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