Drug interactions
Norethisterone + Sugammadex
Severity: Moderate
Norethisterone and Sugammadex: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sugammadex may bind progestogens and reduce their available exposure. Labeling treats a bolus dose as equivalent to a missed dose of a hormonal contraceptive.
What this interaction means in plain words
Norethisterone and Sugammadex can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Norethisterone belongs to Endocrine; Sugammadex belongs to Miscellaneous.
Why it happens
Sugammadex encapsulates progestogen molecules, lowering their free concentration.
What to do
Apply missed-pill advice from the norethisterone product information after sugammadex administration. Patients using implants or patches should use an additional nonhormonal method for the following 7 days.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Sugammadex
- Desogestrel-ethinyl estradiol + Sugammadex Moderate
- Ethinyl estradiol-drospirenone + Sugammadex Moderate
- Ethinyl estradiol-levonorgestrel + Sugammadex Moderate
- Etonogestrel + Sugammadex Moderate
- Levonorgestrel + Sugammadex Moderate
- Medroxyprogesterone + Sugammadex Moderate
Frequently asked questions
Can I take Norethisterone with Sugammadex?
MediHelp rates the interaction as moderate. Norethisterone and Sugammadex can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sugammadex may bind progestogens and reduce their available exposure. Labeling treats a bolus dose as equivalent to a missed dose of a hormonal contraceptive.
How serious is the interaction between Norethisterone and Sugammadex?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Apply missed-pill advice from the norethisterone product information after sugammadex administration. Patients using implants or patches should use an additional nonhormonal method for the following 7 days.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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