Drug interactions
Levonorgestrel + Tazemetostat
Severity: Moderate
Levonorgestrel and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and may reduce levonorgestrel exposure. Its labeling advises that hormonal contraceptives may be less effective, and tazemetostat can cause fetal harm.
What this interaction means in plain words
Levonorgestrel and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levonorgestrel belongs to Endocrine; Tazemetostat belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 by tazemetostat increases levonorgestrel clearance.
What to do
Advise an effective non-hormonal contraceptive method or an added barrier method during treatment and for a period after the last dose, as stated in the tazemetostat label.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levonorgestrel
Other interactions of Tazemetostat
Frequently asked questions
Can I take Levonorgestrel with Tazemetostat?
MediHelp rates the interaction as moderate. Levonorgestrel and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A4 inducer and may reduce levonorgestrel exposure. Its labeling advises that hormonal contraceptives may be less effective, and tazemetostat can cause fetal harm.
How serious is the interaction between Levonorgestrel and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an effective non-hormonal contraceptive method or an added barrier method during treatment and for a period after the last dose, as stated in the tazemetostat label.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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