Drug interactions
Levonorgestrel + Tecovirimat
Severity: Minor
Levonorgestrel and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and may modestly lower levonorgestrel concentrations. The clinical impact on contraceptive efficacy is probably small and short-lived because treatment courses are brief.
What this interaction means in plain words
Levonorgestrel and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levonorgestrel belongs to Endocrine; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 by tecovirimat increases levonorgestrel metabolism.
What to do
Advise a barrier method during and shortly after tecovirimat treatment, especially with oral or emergency levonorgestrel.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levonorgestrel
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Levonorgestrel with Tecovirimat?
MediHelp rates the interaction as minor. Levonorgestrel and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP3A4 inducer and may modestly lower levonorgestrel concentrations. The clinical impact on contraceptive efficacy is probably small and short-lived because treatment courses are brief.
How serious is the interaction between Levonorgestrel and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise a barrier method during and shortly after tecovirimat treatment, especially with oral or emergency levonorgestrel.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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