Drug interactions
Levonorgestrel intrauterine + Nevirapine
Severity: Minor
Levonorgestrel intrauterine and Nevirapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intrauterine system acts mainly locally with low systemic levonorgestrel exposure, so nevirapine induction is unlikely to reduce contraceptive efficacy significantly.
What this interaction means in plain words
Levonorgestrel intrauterine and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nevirapine induces CYP3A4 and may lower systemic levonorgestrel, but local endometrial effect predominates.
What to do
No routine change is needed for the intrauterine system; this is not so for oral levonorgestrel contraceptives.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Levonorgestrel intrauterine with Nevirapine?
MediHelp rates the interaction as minor. Levonorgestrel intrauterine and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The intrauterine system acts mainly locally with low systemic levonorgestrel exposure, so nevirapine induction is unlikely to reduce contraceptive efficacy significantly.
How serious is the interaction between Levonorgestrel intrauterine and Nevirapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for the intrauterine system; this is not so for oral levonorgestrel contraceptives.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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