Drug interactions
Levorphanol + Methamphetamine
Severity: Moderate
Levorphanol and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levorphanol is a potent opioid with sedative and respiratory-depressant effects, while methamphetamine is a stimulant. The stimulant may mask opioid sedation, and when its effect wears off the depressant effect can emerge, so overdose risk may be underestimated.
What this interaction means in plain words
Levorphanol and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS pharmacodynamic effects, with the stimulant masking opioid sedation.
What to do
Monitor respiratory rate and level of consciousness and do not rely on alertness alone. Titrate the opioid conservatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Levorphanol with Methamphetamine?
MediHelp rates the interaction as moderate. Levorphanol and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levorphanol is a potent opioid with sedative and respiratory-depressant effects, while methamphetamine is a stimulant. The stimulant may mask opioid sedation, and when its effect wears off the depressant effect can emerge, so overdose risk may be underestimated.
How serious is the interaction between Levorphanol and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and level of consciousness and do not rely on alertness alone. Titrate the opioid conservatively.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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