Drug interactions
Levorphanol + Modafinil
Severity: Moderate
Levorphanol and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levorphanol is a sedating opioid that opposes the wakefulness effect of modafinil. Modafinil does not reverse opioid respiratory depression, and perceived alertness may mask impairment.
What this interaction means in plain words
Levorphanol and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic CNS effects; no established pharmacokinetic interaction.
What to do
Do not use modafinil to counter opioid sedation; monitor for respiratory depression and impairment when initiating or titrating either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Levorphanol with Modafinil?
MediHelp rates the interaction as moderate. Levorphanol and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levorphanol is a sedating opioid that opposes the wakefulness effect of modafinil. Modafinil does not reverse opioid respiratory depression, and perceived alertness may mask impairment.
How serious is the interaction between Levorphanol and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use modafinil to counter opioid sedation; monitor for respiratory depression and impairment when initiating or titrating either drug.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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