Drug interactions
Levorphanol + Sevoflurane
Severity: Major
Levorphanol and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levorphanol is a potent opioid and together with sevoflurane increases sedation, respiratory depression and hypotension. Anesthetic requirements are reduced and postoperative respiratory depression may be prolonged.
What this interaction means in plain words
Levorphanol and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from mu-opioid agonism combined with volatile anesthetic action.
What to do
Titrate both agents carefully, with reduced sevoflurane concentrations as needed. Monitor respiratory rate, oxygen saturation and sedation continuously, and have an opioid reversal agent available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levorphanol and Sevoflurane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sevoflurane
Frequently asked questions
Can I take Levorphanol with Sevoflurane?
MediHelp rates the interaction as major. Levorphanol and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levorphanol is a potent opioid and together with sevoflurane increases sedation, respiratory depression and hypotension. Anesthetic requirements are reduced and postoperative respiratory depression may be prolonged.
How serious is the interaction between Levorphanol and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate both agents carefully, with reduced sevoflurane concentrations as needed. Monitor respiratory rate, oxygen saturation and sedation continuously, and have an opioid reversal agent available.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
