Drug interactions
Levorphanol + Trazodone
Severity: Major
Levorphanol and Trazodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levorphanol is an opioid, and combining it with sedating drugs such as trazodone increases the risk of profound sedation, respiratory depression and hypotension. Trazodone also has serotonergic activity, which adds a small theoretical risk of serotonin toxicity.
What this interaction means in plain words
Levorphanol and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression, with mild serotonergic contribution.
What to do
Use the lowest effective doses and the shortest duration, and monitor for sedation and respiratory depression. Warn patients to avoid alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Levorphanol with Trazodone?
MediHelp rates the interaction as major. Levorphanol and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levorphanol is an opioid, and combining it with sedating drugs such as trazodone increases the risk of profound sedation, respiratory depression and hypotension. Trazodone also has serotonergic activity, which adds a small theoretical risk of serotonin toxicity.
How serious is the interaction between Levorphanol and Trazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and the shortest duration, and monitor for sedation and respiratory depression. Warn patients to avoid alcohol and driving.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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