Drug interactions
Levosalbutamol + Metolazone
Severity: Moderate
Levosalbutamol and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower serum potassium, so together they can cause clinically significant hypokalemia. This raises the risk of ventricular arrhythmias, particularly with high-dose or repeated levosalbutamol use, in hypoxic patients, or with other arrhythmia risk factors.
What this interaction means in plain words
Levosalbutamol and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levosalbutamol belongs to Respiratory; Metolazone belongs to Cardiovascular.
Why it happens
Additive hypokalemia, from beta-2-mediated intracellular potassium shift with levosalbutamol and renal potassium loss with metolazone.
What to do
Monitor serum potassium and magnesium, especially during acute asthma or COPD exacerbations or when levosalbutamol use is high. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Metolazone
Frequently asked questions
Can I take Levosalbutamol with Metolazone?
MediHelp rates the interaction as moderate. Levosalbutamol and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower serum potassium, so together they can cause clinically significant hypokalemia. This raises the risk of ventricular arrhythmias, particularly with high-dose or repeated levosalbutamol use, in hypoxic patients, or with other arrhythmia risk factors.
How serious is the interaction between Levosalbutamol and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, especially during acute asthma or COPD exacerbations or when levosalbutamol use is high. Replace potassium as needed.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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