Drug interactions
Levosalbutamol + Midodrine
Severity: Moderate
Levosalbutamol and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have adrenergic activity, so combined use may add to increases in blood pressure and heart rate. This matters most in patients with cardiovascular disease, and midodrine can also cause supine hypertension.
What this interaction means in plain words
Levosalbutamol and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levosalbutamol belongs to Respiratory; Midodrine belongs to Miscellaneous.
Why it happens
Additive sympathomimetic effects, from alpha-1 agonism by midodrine and beta-2 agonism by levosalbutamol.
What to do
Monitor blood pressure, including supine readings, and heart rate. Reduce the dose of either drug if hypertension or tachycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Levosalbutamol with Midodrine?
MediHelp rates the interaction as moderate. Levosalbutamol and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have adrenergic activity, so combined use may add to increases in blood pressure and heart rate. This matters most in patients with cardiovascular disease, and midodrine can also cause supine hypertension.
How serious is the interaction between Levosalbutamol and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine readings, and heart rate. Reduce the dose of either drug if hypertension or tachycardia develops.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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