Drug interactions
Levothyroxine + Linagliptin-metformin
Severity: Moderate
Levothyroxine and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone increases glucose production and absorption and can worsen glycemic control. Starting or increasing levothyroxine may raise antidiabetic requirements.
What this interaction means in plain words
Levothyroxine and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levothyroxine belongs to Endocrine; Linagliptin-metformin belongs to Endocrine.
Why it happens
Thyroid hormone increases hepatic gluconeogenesis, glycogenolysis and metabolic rate.
What to do
Monitor glucose when levothyroxine is started or adjusted and titrate antidiabetic drugs accordingly. Watch for hypoglycemia if the thyroid dose is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Levothyroxine
Frequently asked questions
Can I take Levothyroxine with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Levothyroxine and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone increases glucose production and absorption and can worsen glycemic control. Starting or increasing levothyroxine may raise antidiabetic requirements.
How serious is the interaction between Levothyroxine and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when levothyroxine is started or adjusted and titrate antidiabetic drugs accordingly. Watch for hypoglycemia if the thyroid dose is reduced.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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