Drug interactions
Levothyroxine + Secobarbital
Severity: Moderate
Levothyroxine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzyme-inducing barbiturates can increase thyroxine clearance, potentially raising levothyroxine requirements and causing hypothyroidism in treated patients.
What this interaction means in plain words
Levothyroxine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levothyroxine belongs to Endocrine; Secobarbital belongs to Central Nervous System.
Why it happens
Hepatic enzyme induction increases glucuronidation and metabolism of thyroid hormone.
What to do
Check TSH after starting or stopping secobarbital and adjust the levothyroxine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Levothyroxine
Frequently asked questions
Can I take Levothyroxine with Secobarbital?
MediHelp rates the interaction as moderate. Levothyroxine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzyme-inducing barbiturates can increase thyroxine clearance, potentially raising levothyroxine requirements and causing hypothyroidism in treated patients.
How serious is the interaction between Levothyroxine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check TSH after starting or stopping secobarbital and adjust the levothyroxine dose accordingly.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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