Drug interactions
Levothyroxine + Ustekinumab
Severity: Minor
Levothyroxine and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levothyroxine is not primarily cleared by CYP450 enzymes, so the cytokine-related enzyme effect of ustekinumab is unlikely to affect it.
What this interaction means in plain words
Levothyroxine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levothyroxine belongs to Endocrine; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
No established mechanism; theoretical CYP effect is not relevant to levothyroxine metabolism.
What to do
No specific action beyond routine TSH monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Levothyroxine
Frequently asked questions
Can I take Levothyroxine with Ustekinumab?
MediHelp rates the interaction as minor. Levothyroxine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levothyroxine is not primarily cleared by CYP450 enzymes, so the cytokine-related enzyme effect of ustekinumab is unlikely to affect it.
How serious is the interaction between Levothyroxine and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action beyond routine TSH monitoring.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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