Drug interactions
Lidocaine + Lomitapide
Severity: Minor
Lidocaine and Lomitapide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a sensitive CYP3A4 substrate, and its levels rise markedly with strong or moderate CYP3A4 inhibitors. Lidocaine is a CYP3A4 substrate and not a meaningful inhibitor, so a large increase is not expected. The interaction is theoretical.
What this interaction means in plain words
Lidocaine and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.
Why it happens
Possible minor competition for CYP3A4 metabolism; lidocaine is not an established CYP3A4 inhibitor.
What to do
No dose change is usually needed; monitor liver enzymes as routinely required for lomitapide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lidocaine with Lomitapide?
MediHelp rates the interaction as minor. Lidocaine and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomitapide is a sensitive CYP3A4 substrate, and its levels rise markedly with strong or moderate CYP3A4 inhibitors. Lidocaine is a CYP3A4 substrate and not a meaningful inhibitor, so a large increase is not expected. The interaction is theoretical.
How serious is the interaction between Lidocaine and Lomitapide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor liver enzymes as routinely required for lomitapide.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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