Drug interactions
Lidocaine + Lonafarnib
Severity: Minor
Lidocaine and Lonafarnib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate and its exposure rises with CYP3A inhibitors. Lidocaine is only a weak inhibitor, so a meaningful rise is unlikely, but lonafarnib can cause QT and gastrointestinal effects.
What this interaction means in plain words
Lidocaine and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine belongs to Cardiovascular; Lonafarnib belongs to Miscellaneous.
Why it happens
Weak CYP3A4 inhibition by lidocaine may modestly reduce lonafarnib metabolism.
What to do
No routine dose change; monitor for lonafarnib adverse effects, especially arrhythmia symptoms, during prolonged systemic lidocaine use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lidocaine with Lonafarnib?
MediHelp rates the interaction as minor. Lidocaine and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a sensitive CYP3A substrate and its exposure rises with CYP3A inhibitors. Lidocaine is only a weak inhibitor, so a meaningful rise is unlikely, but lonafarnib can cause QT and gastrointestinal effects.
How serious is the interaction between Lidocaine and Lonafarnib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for lonafarnib adverse effects, especially arrhythmia symptoms, during prolonged systemic lidocaine use.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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