Drug interactions
Lidocaine + Sonidegib
Severity: Minor
Lidocaine and Sonidegib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic lidocaine is a weak to moderate CYP3A4 inhibitor and could modestly raise sonidegib exposure. Sonidegib is associated with musculoskeletal toxicity and creatine kinase elevation, which are exposure related.
What this interaction means in plain words
Lidocaine and Sonidegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine belongs to Cardiovascular; Sonidegib belongs to Oncology.
Why it happens
Lidocaine may inhibit CYP3A4-mediated metabolism of sonidegib, increasing its plasma concentration.
What to do
Local or short-term lidocaine use needs no change. If prolonged systemic lidocaine is required, monitor for muscle pain, weakness and rising creatine kinase.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Lidocaine with Sonidegib?
MediHelp rates the interaction as minor. Lidocaine and Sonidegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic lidocaine is a weak to moderate CYP3A4 inhibitor and could modestly raise sonidegib exposure. Sonidegib is associated with musculoskeletal toxicity and creatine kinase elevation, which are exposure related.
How serious is the interaction between Lidocaine and Sonidegib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Local or short-term lidocaine use needs no change. If prolonged systemic lidocaine is required, monitor for muscle pain, weakness and rising creatine kinase.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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