Drug interactions
Lidocaine-prilocaine + Oliceridine
Severity: Minor
Lidocaine-prilocaine and Oliceridine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lidocaine may inhibit CYP2D6 and could increase oliceridine exposure, with a risk of excess sedation and respiratory depression. With topical lidocaine-prilocaine the systemic effect is small, so the interaction is mainly relevant with extensive use.
What this interaction means in plain words
Lidocaine-prilocaine and Oliceridine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine-prilocaine belongs to Genitourinary; Oliceridine belongs to Musculoskeletal.
Why it happens
Possible CYP2D6 inhibition by lidocaine reduces oliceridine metabolism.
What to do
Monitor for sedation and respiratory depression and titrate oliceridine to effect. No routine dose change is needed for limited topical application.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Lidocaine-prilocaine with Oliceridine?
MediHelp rates the interaction as minor. Lidocaine-prilocaine and Oliceridine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lidocaine may inhibit CYP2D6 and could increase oliceridine exposure, with a risk of excess sedation and respiratory depression. With topical lidocaine-prilocaine the systemic effect is small, so the interaction is mainly relevant with extensive use.
How serious is the interaction between Lidocaine-prilocaine and Oliceridine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and titrate oliceridine to effect. No routine dose change is needed for limited topical application.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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