Drug interactions
Linagliptin + Rifampin
Severity: Moderate
Linagliptin and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin markedly reduces linagliptin exposure and DPP-4 inhibition in pharmacokinetic studies. The labeling notes that efficacy may be lost, so glycemic control may worsen.
What this interaction means in plain words
Linagliptin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces P-glycoprotein and CYP3A4, increasing linagliptin elimination.
What to do
Monitor blood glucose closely during rifampin therapy. Switch to a different antidiabetic agent if control is inadequate, as labeling advises considering alternatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Linagliptin and Rifampin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Linagliptin with Rifampin?
MediHelp rates the interaction as moderate. Linagliptin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin markedly reduces linagliptin exposure and DPP-4 inhibition in pharmacokinetic studies. The labeling notes that efficacy may be lost, so glycemic control may worsen.
How serious is the interaction between Linagliptin and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during rifampin therapy. Switch to a different antidiabetic agent if control is inadequate, as labeling advises considering alternatives.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
