Drug interactions
Linagliptin-metformin + Linezolid
Severity: Moderate
Linagliptin-metformin and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid, a weak MAO inhibitor, has been associated with hypoglycemia in patients taking insulin or oral antidiabetic agents. Metformin alone rarely causes hypoglycemia, but the combination with other agents raises risk.
What this interaction means in plain words
Linagliptin-metformin and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Linezolid belongs to Anti Bacterial.
Why it happens
Linezolid may enhance glucose lowering, possibly via MAO inhibition; the mechanism is not firmly established.
What to do
Monitor blood glucose during linezolid therapy. Reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Linezolid?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid, a weak MAO inhibitor, has been associated with hypoglycemia in patients taking insulin or oral antidiabetic agents. Metformin alone rarely causes hypoglycemia, but the combination with other agents raises risk.
How serious is the interaction between Linagliptin-metformin and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during linezolid therapy. Reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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