Drug interactions
Linagliptin-metformin + Maprotiline
Severity: Minor
Linagliptin-metformin and Maprotiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants such as maprotiline may alter glycemic control and occasionally enhance glucose lowering. The clinical effect with metformin is expected to be small.
What this interaction means in plain words
Linagliptin-metformin and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin-metformin belongs to Endocrine; Maprotiline belongs to Central Nervous System.
Why it happens
Proposed additive effects on glucose metabolism; the mechanism is not firmly established.
What to do
Monitor blood glucose when maprotiline is started or stopped and adjust therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Maprotiline?
MediHelp rates the interaction as minor. Linagliptin-metformin and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antidepressants such as maprotiline may alter glycemic control and occasionally enhance glucose lowering. The clinical effect with metformin is expected to be small.
How serious is the interaction between Linagliptin-metformin and Maprotiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when maprotiline is started or stopped and adjust therapy if needed.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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