Drug interactions
Linagliptin-metformin + Mifepristone
Severity: Minor
Linagliptin-metformin and Mifepristone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may modestly raise linagliptin exposure, which has a wide safety margin. In Cushing syndrome, mifepristone can also lower glucose and increase hypoglycemia risk.
What this interaction means in plain words
Linagliptin-metformin and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin-metformin belongs to Endocrine; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition reduces linagliptin metabolism, and glucocorticoid receptor blockade may lower glucose.
What to do
No linagliptin dose change is usually needed. Monitor blood glucose when mifepristone is used long-term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Mifepristone?
MediHelp rates the interaction as minor. Linagliptin-metformin and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone inhibits CYP3A4 and may modestly raise linagliptin exposure, which has a wide safety margin. In Cushing syndrome, mifepristone can also lower glucose and increase hypoglycemia risk.
How serious is the interaction between Linagliptin-metformin and Mifepristone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No linagliptin dose change is usually needed. Monitor blood glucose when mifepristone is used long-term.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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