Drug interactions
Linagliptin-metformin + Mitotane
Severity: Moderate
Linagliptin-metformin and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and can substantially lower linagliptin concentrations, potentially leading to loss of glycemic control. The effect can persist for weeks after mitotane is stopped because of its long half-life.
What this interaction means in plain words
Linagliptin-metformin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Mitotane belongs to Oncology.
Why it happens
Induction of CYP3A4 (and likely P-gp) increases linagliptin clearance.
What to do
Monitor glucose and HbA1c and consider an alternative antidiabetic agent if control is lost. Continue monitoring for weeks after mitotane discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Linagliptin-metformin with Mitotane?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and can substantially lower linagliptin concentrations, potentially leading to loss of glycemic control. The effect can persist for weeks after mitotane is stopped because of its long half-life.
How serious is the interaction between Linagliptin-metformin and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c and consider an alternative antidiabetic agent if control is lost. Continue monitoring for weeks after mitotane discontinuation.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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