Drug interactions
Linagliptin-metformin + Prednisone
Severity: Moderate
Linagliptin-metformin and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisone is a corticosteroid that raises blood glucose and can substantially worsen control in diabetes, countering linagliptin-metformin. Effect depends on dose and duration.
What this interaction means in plain words
Linagliptin-metformin and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Prednisone belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and peripheral insulin resistance, opposing glucose-lowering therapy.
What to do
Monitor glucose closely during steroid courses, particularly postprandial values, and escalate antidiabetic therapy temporarily, reducing it again as the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Linagliptin-metformin with Prednisone?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prednisone is a corticosteroid that raises blood glucose and can substantially worsen control in diabetes, countering linagliptin-metformin. Effect depends on dose and duration.
How serious is the interaction between Linagliptin-metformin and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely during steroid courses, particularly postprandial values, and escalate antidiabetic therapy temporarily, reducing it again as the steroid is tapered.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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