Drug interactions
Linagliptin-metformin + Procarbazine
Severity: Minor
Linagliptin-metformin and Procarbazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak MAO-inhibiting activity, and MAO inhibitors have been associated with enhanced glucose lowering. The evidence for a clinically relevant effect with metformin and linagliptin is limited.
What this interaction means in plain words
Linagliptin-metformin and Procarbazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin-metformin belongs to Endocrine; Procarbazine belongs to Oncology.
Why it happens
Possible enhancement of insulin sensitivity via MAO inhibition; the mechanism is not established.
What to do
Monitor blood glucose during procarbazine therapy and adjust antidiabetic doses if hypoglycemia or hyperglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Procarbazine?
MediHelp rates the interaction as minor. Linagliptin-metformin and Procarbazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Procarbazine has weak MAO-inhibiting activity, and MAO inhibitors have been associated with enhanced glucose lowering. The evidence for a clinically relevant effect with metformin and linagliptin is limited.
How serious is the interaction between Linagliptin-metformin and Procarbazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during procarbazine therapy and adjust antidiabetic doses if hypoglycemia or hyperglycemia occurs.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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