Drug interactions
Linagliptin-metformin + Quinidine
Severity: Moderate
Linagliptin-metformin and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a cationic drug that may reduce the renal tubular secretion of metformin. This can raise metformin exposure and increase the risk of adverse effects including lactic acidosis, especially in renal impairment.
What this interaction means in plain words
Linagliptin-metformin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Competition for renal tubular secretion via OCT2 and MATE transporters, reducing metformin clearance.
What to do
Monitor glycemic control and renal function, and consider reducing the metformin dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Quinidine?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine is a cationic drug that may reduce the renal tubular secretion of metformin. This can raise metformin exposure and increase the risk of adverse effects including lactic acidosis, especially in renal impairment.
How serious is the interaction between Linagliptin-metformin and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function, and consider reducing the metformin dose if adverse effects appear.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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