Drug interactions
Linagliptin-metformin + Sertraline
Severity: Minor
Linagliptin-metformin and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs such as sertraline may modestly enhance glucose lowering and have been associated with hypoglycemia in patients on antidiabetic drugs. The effect is variable and usually mild with metformin-based therapy.
What this interaction means in plain words
Linagliptin-metformin and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin-metformin belongs to Endocrine; Sertraline belongs to Central Nervous System.
Why it happens
Possible additive glucose-lowering effect through improved insulin sensitivity; mechanism is not well established.
What to do
Be aware of possible hypoglycemia and check blood glucose when starting or stopping sertraline.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Sertraline?
MediHelp rates the interaction as minor. Linagliptin-metformin and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. SSRIs such as sertraline may modestly enhance glucose lowering and have been associated with hypoglycemia in patients on antidiabetic drugs. The effect is variable and usually mild with metformin-based therapy.
How serious is the interaction between Linagliptin-metformin and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of possible hypoglycemia and check blood glucose when starting or stopping sertraline.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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