Drug interactions
Linagliptin-metformin + Thioridazine
Severity: Moderate
Linagliptin-metformin and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as thioridazine can raise blood glucose and worsen glycemic control. Stopping the phenothiazine later may cause glucose to fall, increasing hypoglycemia risk.
What this interaction means in plain words
Linagliptin-metformin and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Thioridazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism via antipsychotic-induced insulin resistance and reduced insulin secretion.
What to do
Monitor blood glucose when thioridazine is started, adjusted or withdrawn, and adjust antidiabetic doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Thioridazine?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines such as thioridazine can raise blood glucose and worsen glycemic control. Stopping the phenothiazine later may cause glucose to fall, increasing hypoglycemia risk.
How serious is the interaction between Linagliptin-metformin and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when thioridazine is started, adjusted or withdrawn, and adjust antidiabetic doses accordingly.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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