Drug interactions
Linagliptin-metformin + Tolbutamide
Severity: Moderate
Linagliptin-metformin and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding a DPP-4 inhibitor to a sulfonylurea increases the risk of hypoglycemia. Metformin combined with a sulfonylurea adds to this glucose-lowering effect.
What this interaction means in plain words
Linagliptin-metformin and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Additive glucose-lowering effect, as linagliptin enhances glucose-dependent insulin secretion on top of sulfonylurea-driven insulin release.
What to do
Consider lowering the tolbutamide dose when starting the combination and counsel the patient on recognizing and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Linagliptin-metformin with Tolbutamide?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding a DPP-4 inhibitor to a sulfonylurea increases the risk of hypoglycemia. Metformin combined with a sulfonylurea adds to this glucose-lowering effect.
How serious is the interaction between Linagliptin-metformin and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the tolbutamide dose when starting the combination and counsel the patient on recognizing and treating hypoglycemia.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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