Drug interactions
Linagliptin-metformin + Trilaciclib
Severity: Major
Linagliptin-metformin and Trilaciclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits OCT2, MATE1 and MATE2-K, which raises metformin exposure rather than lowering it. This may increase the risk of metformin toxicity including lactic acidosis.
What this interaction means in plain words
Linagliptin-metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linagliptin-metformin belongs to Endocrine; Trilaciclib belongs to Oncology.
Why it happens
Trilaciclib inhibits renal OCT2 and MATE transporters, reducing metformin elimination.
What to do
Avoid concurrent use where possible, or hold metformin on the days of trilaciclib infusion. Monitor renal function and lactate-related symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linagliptin-metformin
Other interactions of Trilaciclib
Frequently asked questions
Can I take Linagliptin-metformin with Trilaciclib?
MediHelp rates the interaction as major. Linagliptin-metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trilaciclib inhibits OCT2, MATE1 and MATE2-K, which raises metformin exposure rather than lowering it. This may increase the risk of metformin toxicity including lactic acidosis.
How serious is the interaction between Linagliptin-metformin and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, or hold metformin on the days of trilaciclib infusion. Monitor renal function and lactate-related symptoms.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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