Drug interactions
Linagliptin-metformin + Verapamil
Severity: Minor
Linagliptin-metformin and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may inhibit hepatic uptake of metformin and has been shown to reduce its glucose-lowering effect in some studies. The effect on glycemic control is usually modest.
What this interaction means in plain words
Linagliptin-metformin and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin-metformin belongs to Endocrine; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of OCT1-mediated hepatic uptake of metformin reduces access to its site of action.
What to do
Monitor glycemic control when verapamil is started or stopped and adjust metformin if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Linagliptin-metformin with Verapamil?
MediHelp rates the interaction as minor. Linagliptin-metformin and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil may inhibit hepatic uptake of metformin and has been shown to reduce its glucose-lowering effect in some studies. The effect on glycemic control is usually modest.
How serious is the interaction between Linagliptin-metformin and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when verapamil is started or stopped and adjust metformin if needed.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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