Drug interactions
Linezolid + Loxapine
Severity: Moderate
Linezolid and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid inhibits MAO and loxapine blocks dopamine and serotonin receptors, so serotonin toxicity and additive neuroleptic malignant syndrome features are theoretically possible. Documented cases are uncommon.
What this interaction means in plain words
Linezolid and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linezolid belongs to Anti Bacterial; Loxapine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic and dopamine-blocking effects with MAO inhibition by linezolid.
What to do
Monitor for hyperthermia, rigidity, clonus, agitation and autonomic instability during linezolid therapy. Stop the drugs and treat supportively if suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Linezolid with Loxapine?
MediHelp rates the interaction as moderate. Linezolid and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid inhibits MAO and loxapine blocks dopamine and serotonin receptors, so serotonin toxicity and additive neuroleptic malignant syndrome features are theoretically possible. Documented cases are uncommon.
How serious is the interaction between Linezolid and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hyperthermia, rigidity, clonus, agitation and autonomic instability during linezolid therapy. Stop the drugs and treat supportively if suspected.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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