Drug interactions
Linezolid + Naratriptan
Severity: Major
Linezolid and Naratriptan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid's MAO-inhibiting activity combined with a triptan raises the risk of serotonin syndrome. Naratriptan is not mainly metabolized by MAO, so its exposure rise is limited, but the serotonergic concern remains.
What this interaction means in plain words
Linezolid and Naratriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linezolid belongs to Anti Bacterial; Naratriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effect from MAO inhibition and 5-HT1B/1D agonism.
What to do
Avoid the combination where possible and use non-serotonergic acute migraine treatment during linezolid therapy; if used together, monitor for agitation, tremor, hyperthermia and clonus.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Linezolid with Naratriptan?
MediHelp rates the interaction as major. Linezolid and Naratriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Linezolid's MAO-inhibiting activity combined with a triptan raises the risk of serotonin syndrome. Naratriptan is not mainly metabolized by MAO, so its exposure rise is limited, but the serotonergic concern remains.
How serious is the interaction between Linezolid and Naratriptan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use non-serotonergic acute migraine treatment during linezolid therapy; if used together, monitor for agitation, tremor, hyperthermia and clonus.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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