Drug interactions
Linezolid + Oliceridine
Severity: Major
Linezolid and Oliceridine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid is a weak MAO inhibitor and opioids can have serotonergic activity, so serotonin syndrome is possible. Opioid-related CNS and respiratory depression may also be enhanced.
What this interaction means in plain words
Linezolid and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linezolid belongs to Anti Bacterial; Oliceridine belongs to Musculoskeletal.
Why it happens
MAO inhibition by linezolid combined with opioid-related serotonergic effects.
What to do
Avoid if alternatives exist; otherwise monitor for agitation, hyperthermia, clonus and respiratory depression and start with low opioid doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Linezolid with Oliceridine?
MediHelp rates the interaction as major. Linezolid and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Linezolid is a weak MAO inhibitor and opioids can have serotonergic activity, so serotonin syndrome is possible. Opioid-related CNS and respiratory depression may also be enhanced.
How serious is the interaction between Linezolid and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if alternatives exist; otherwise monitor for agitation, hyperthermia, clonus and respiratory depression and start with low opioid doses.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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