Drug interactions
Linezolid + Procarbazine
Severity: Major
Linezolid and Procarbazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid is a reversible non-selective MAO inhibitor, and procarbazine also has weak MAO-inhibiting activity. Together they can raise central serotonergic and adrenergic activity, with a risk of serotonin syndrome (agitation, hyperthermia, clonus, autonomic instability) and hypertensive reactions.
What this interaction means in plain words
Linezolid and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linezolid belongs to Anti Bacterial; Procarbazine belongs to Oncology.
Why it happens
Additive MAO inhibition leading to excess synaptic serotonin and catecholamines.
What to do
Prefer an alternative antibacterial where possible. If linezolid is essential, monitor closely for serotonin toxicity and blood pressure changes during and for about two weeks after the combination.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Linezolid and Procarbazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Linezolid with Procarbazine?
MediHelp rates the interaction as major. Linezolid and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Linezolid is a reversible non-selective MAO inhibitor, and procarbazine also has weak MAO-inhibiting activity. Together they can raise central serotonergic and adrenergic activity, with a risk of serotonin syndrome (agitation, hyperthermia, clonus, autonomic instability) and hypertensive reactions.
How serious is the interaction between Linezolid and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibacterial where possible. If linezolid is essential, monitor closely for serotonin toxicity and blood pressure changes during and for about two weeks after the combination.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
