Drug interactions
Linezolid + Quetiapine
Severity: Moderate
Linezolid and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid inhibits MAO and quetiapine acts on serotonin and dopamine receptors. Serotonin syndrome or neuroleptic malignant syndrome is possible but uncommon. Quetiapine sedation may also mask early signs.
What this interaction means in plain words
Linezolid and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linezolid belongs to Anti Bacterial; Quetiapine belongs to Central Nervous System.
Why it happens
Additive serotonergic and dopaminergic effects from MAO inhibition plus antipsychotic receptor activity.
What to do
Monitor for agitation, tremor, clonus, fever and rigidity during the linezolid course. Discontinue the agents and give supportive care if features appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Linezolid with Quetiapine?
MediHelp rates the interaction as moderate. Linezolid and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid inhibits MAO and quetiapine acts on serotonin and dopamine receptors. Serotonin syndrome or neuroleptic malignant syndrome is possible but uncommon. Quetiapine sedation may also mask early signs.
How serious is the interaction between Linezolid and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, clonus, fever and rigidity during the linezolid course. Discontinue the agents and give supportive care if features appear.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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