Drug interactions
Linezolid + Saxagliptin-metformin
Severity: Moderate
Linezolid and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid has been associated with hypoglycemia in patients with diabetes treated with insulin or oral hypoglycemics. It has also been linked to lactic acidosis through mitochondrial toxicity, which is relevant in patients taking metformin.
What this interaction means in plain words
Linezolid and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linezolid belongs to Anti Bacterial; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Mechanism is not firmly established; linezolid may enhance glucose lowering, and its mitochondrial toxicity may add to metformin-associated lactic acidosis risk.
What to do
Monitor blood glucose during linezolid therapy and counsel patients about hypoglycemia symptoms. Evaluate promptly for lactic acidosis if nausea, vomiting, malaise or tachypnea develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Linezolid and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid has been associated with hypoglycemia in patients with diabetes treated with insulin or oral hypoglycemics. It has also been linked to lactic acidosis through mitochondrial toxicity, which is relevant in patients taking metformin.
How serious is the interaction between Linezolid and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during linezolid therapy and counsel patients about hypoglycemia symptoms. Evaluate promptly for lactic acidosis if nausea, vomiting, malaise or tachypnea develop.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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