Drug interactions
Linezolid + Tolbutamide
Severity: Moderate
Linezolid and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid labeling warns of hypoglycemia in diabetic patients using insulin or oral hypoglycemic agents. Tolbutamide may therefore produce stronger glucose lowering when linezolid is given.
What this interaction means in plain words
Linezolid and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linezolid belongs to Anti Bacterial; Tolbutamide belongs to Endocrine.
Why it happens
Mechanism not established; possible additive hypoglycemic effect.
What to do
Monitor blood glucose frequently while on linezolid and lower the tolbutamide dose if hypoglycemia develops. Educate the patient on recognising hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Linezolid and Tolbutamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Linezolid with Tolbutamide?
MediHelp rates the interaction as moderate. Linezolid and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid labeling warns of hypoglycemia in diabetic patients using insulin or oral hypoglycemic agents. Tolbutamide may therefore produce stronger glucose lowering when linezolid is given.
How serious is the interaction between Linezolid and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently while on linezolid and lower the tolbutamide dose if hypoglycemia develops. Educate the patient on recognising hypoglycemia.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
