Drug interactions
Linezolid + Tranylcypromine
Severity: Contraindicated
Linezolid and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine is an irreversible non-selective MAO inhibitor, and linezolid adds further MAO inhibition. This stacks the risks of severe serotonin syndrome and hypertensive crisis.
What this interaction means in plain words
Linezolid and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Linezolid belongs to Anti Bacterial; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive inhibition of MAO-A and MAO-B causing excess serotonin and catecholamines.
What to do
Do not combine them; use a non-MAO-inhibiting antibiotic. In an urgent case where linezolid is essential, stop tranylcypromine and observe closely, recognising the prolonged MAO inhibition after discontinuation.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Linezolid with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Linezolid and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tranylcypromine is an irreversible non-selective MAO inhibitor, and linezolid adds further MAO inhibition. This stacks the risks of severe serotonin syndrome and hypertensive crisis.
How serious is the interaction between Linezolid and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine them; use a non-MAO-inhibiting antibiotic. In an urgent case where linezolid is essential, stop tranylcypromine and observe closely, recognising the prolonged MAO inhibition after discontinuation.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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