Drug interactions
Linezolid + Ziprasidone
Severity: Moderate
Linezolid and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid inhibits MAO and ziprasidone has serotonergic and dopaminergic receptor effects, so serotonin toxicity or neuroleptic malignant syndrome is possible though uncommon. Ziprasidone also prolongs the QT interval, which matters if other risks coexist.
What this interaction means in plain words
Linezolid and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linezolid belongs to Anti Bacterial; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive serotonergic and dopaminergic effects from MAO inhibition plus antipsychotic receptor activity.
What to do
Monitor for clonus, agitation, hyperthermia and rigidity during linezolid therapy and keep electrolytes and QT in view. Stop the agents and treat supportively if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Linezolid with Ziprasidone?
MediHelp rates the interaction as moderate. Linezolid and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid inhibits MAO and ziprasidone has serotonergic and dopaminergic receptor effects, so serotonin toxicity or neuroleptic malignant syndrome is possible though uncommon. Ziprasidone also prolongs the QT interval, which matters if other risks coexist.
How serious is the interaction between Linezolid and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clonus, agitation, hyperthermia and rigidity during linezolid therapy and keep electrolytes and QT in view. Stop the agents and treat supportively if toxicity develops.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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