Drug interactions
Liotrix + Trimipramine
Severity: Moderate
Liotrix and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liotrix contains thyroid hormones that can increase adrenergic receptor sensitivity and enhance tricyclic antidepressant effects. This can lead to arrhythmias and CNS stimulation.
What this interaction means in plain words
Liotrix and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased adrenergic receptor sensitivity with additive cardiovascular and CNS stimulation.
What to do
Monitor heart rate, rhythm and mood, and watch for signs of tricyclic toxicity. Check thyroid function and adjust the doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Liotrix with Trimipramine?
MediHelp rates the interaction as moderate. Liotrix and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liotrix contains thyroid hormones that can increase adrenergic receptor sensitivity and enhance tricyclic antidepressant effects. This can lead to arrhythmias and CNS stimulation.
How serious is the interaction between Liotrix and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and mood, and watch for signs of tricyclic toxicity. Check thyroid function and adjust the doses as needed.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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