Drug interactions
Liposomal doxorubicin + Nifedipine
Severity: Minor
Liposomal doxorubicin and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine has been reported to affect P-glycoprotein and doxorubicin disposition, though the direction and clinical importance are uncertain. No clear clinically meaningful interaction is established.
What this interaction means in plain words
Liposomal doxorubicin and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Liposomal doxorubicin belongs to Oncology; Nifedipine belongs to Cardiovascular.
Why it happens
Possible modulation of P-glycoprotein; effect on doxorubicin exposure is not well established.
What to do
No dose adjustment is needed. Monitor treatment response and toxicity as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Nifedipine
Frequently asked questions
Can I take Liposomal doxorubicin with Nifedipine?
MediHelp rates the interaction as minor. Liposomal doxorubicin and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine has been reported to affect P-glycoprotein and doxorubicin disposition, though the direction and clinical importance are uncertain. No clear clinically meaningful interaction is established.
How serious is the interaction between Liposomal doxorubicin and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor treatment response and toxicity as usual.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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