Drug interactions
Liposomal doxorubicin + Rifabutin
Severity: Minor
Liposomal doxorubicin and Rifabutin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and may reduce doxorubicin exposure, possibly lowering efficacy. Induction by rifabutin is weaker than by rifampicin and CYP3A4 is a minor route for doxorubicin, so the effect is likely small.
What this interaction means in plain words
Liposomal doxorubicin and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Liposomal doxorubicin belongs to Oncology; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induction of CYP3A4 and possibly P-glycoprotein may modestly increase doxorubicin clearance.
What to do
No routine adjustment; monitor clinical response to chemotherapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Liposomal doxorubicin with Rifabutin?
MediHelp rates the interaction as minor. Liposomal doxorubicin and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifabutin induces CYP3A4 and may reduce doxorubicin exposure, possibly lowering efficacy. Induction by rifabutin is weaker than by rifampicin and CYP3A4 is a minor route for doxorubicin, so the effect is likely small.
How serious is the interaction between Liposomal doxorubicin and Rifabutin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor clinical response to chemotherapy.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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